Wednesday, June 24, 2015

Metadoxine for fragile X---intermediate results

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Alcobra just announced results from their trial of a proprietary formulation of metadoxine in fragile X subjects, and there is a glimmer of ...
Tuesday, March 10, 2015

Re-examining the nature of fragile X

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In the wake of negative results from several high-profile clinical trials in fragile X, we find ourselves questioning all of our previous as...
Tuesday, December 9, 2014

Pharmacogenomic Testing in Psychiatry

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A fellow clinician asked me what I thought about "pharmacogenomic testing" services which are now being offered, and heavily promo...
Tuesday, November 25, 2014

Something to be thankful for---a major success for Neuren

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This isn’t a fragile X trial, but the same Neuren compound that is in trials now for fragile X (NNZ-2566) has shown significant positive eff...
Thursday, October 23, 2014

Here's a question we get all the time: I was wondering if the protein needed can be delivered another way, gene therapy, or via bacteria perhaps?

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Many people who are new to fragile X ask us about protein replacement strategies of one kind or another; it's an excellent question, and...
Wednesday, October 22, 2014

Can eating broccoli cure autism (or fragile X)?

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A fascinating new study is getting a lot of attention lately, so I decided to give it a closer read. A group of MGH, Harvard, and UMass aut...
Wednesday, September 24, 2014

More bad news...but then some good news for fragile X research

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Let's get the bad news out of the way first---Roche announced that the clinical trial of its lead mGluR5 antagonist for fragile X had f...